We have received few incidents wherein users were not able to start ColdFusion services after server reboot or while restarting the services manually.
Applications dynamically generate ColdFusion files and sometimes also deletes them, but ColdFusion does not remove any old files from the cfclasses folder.
If you have a huge number of websites on one ColdFusion server, it creates thousands of cfclasses depending on number of incoming requests.
Deleting all the class files of cfclasses folder and restarting the ColdFusion server.
If you are unable to delete the files, rename cfclasses folder and create an empty cfclasses in the same location.
To avoid such issues in future, you can manually delete class files at regular time intervals.
If you do not wish to save the class files, you can disable this feature in administrator from Server Settings > Caching
Save class files
When you select this option, the class files generated by ColdFusion are saved to disk for reuse after the server restarts. Adobe recommends this for production systems. During development, Adobe recommends that you do not select this option.